In general case the transformation of image it is possible to present as transformation of contour, and transformations of regions bounded by contour. For the complex contours the transformation of contours of images in affine space results in the significant error. With the purpose of decreasing of error of transformation the adoption of topological space is offered. The method and algorithms of transformation of regions are based on the construction of skeletons of images and next transformations a "region to region". The theorem, which states that in the case when an region is bounded by a piecewise-linear border then a skeleton is piecewise-linear, is proven. Transformation for the cases of isomorphic and not isomorphic skeletons is considered. For software realization of the offered algorithms the integrated development environment Borland Delphi 7.0 and libraries of classes, procedures and functions for work with the graphs GTL and AGraph is used.